Centrophenoxine – Chemical Exchange

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Centrophenoxine

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Procholinergic with nootropic properties. Mild cerebral activator.

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Chemical Information

CAS Number 3685-84-5
Purity 99.6%
Molecular Weight 294.17 g/mol
Molecular Formula C12H17CI2NO3
Synonyms Meclofenoxate hydrochloride, Cerutil, Lucidril, Centrophenoxine hydrochloride, Centrophenoxine, Helfergin, Marucotol, Acefen, Atsefen, Brenal, Centrofenoxin, Amipolen, Cellative, Proserout, 3685-84-5, Meclophenoxate hydrochloride, Methoxynal, Lutiaron, Lucidryl hydrochloride, Dimethylaminoethyl p-chlorophenoxyacetate hydrochloride, NSC 4268, EINECS 222-975-3, Dimethylaminoethyl 4-chlorophenoxyacetate hydrochloride, 2-(dimethylamino)ethyl (4-chlorophenoxy)acetate hydrochloride, 2-(Dimethylamino)ethyl (p-chlorophenoxy)acetate hydrochloride, (p-Chlorophenoxy)acetic acid 2-(dimethylamino)ethyl ester hydrochloride, 4-chlorophenoxy-acetic acid 2-(dimethylamino)ethyl ester hydrochloride, Dimethylaminoethyl ester of p-chlorophenoxyacetic acid hydrochloride, CAS-3685-84-5, Methocynal, Centrophenoxine HCl, 2-dimethylaminoethyl (4-chlorophenoxy)acetate hydrochloride
PubChem CID 19379
Smiles CN(C)CCOC(=O)COC1=CC=C(C=C1)Cl.Cl

Technical Information

Application Meclofenoxate (Lucidril, centrophenoxine) is a procholinergic clinically shown to aid memory, increase cellular membrane phospholipids, and improve general cognition in the elderly. It is used in neuroscience research into the cholinergic signaling system.
Appearance White or off-white powder
Physical State Solid
Solubility Soluble in water. Sparingly soluble in cold isopropyl alcohol, acetone. Practically insoluble in benzene, ether, chloroform.
Storage Store at room temperature or cooler, in a sealed airtight container, protected from heat, light and humidity.
Stability Stable for at least two years when stored as above.

Biochemical Activity

Centrophenoxine (Meclofenoxate, Lucidril) is a cholinergic research compound that has been marketed as a pharmaceutical and is used in the treatment of cognitive symptoms of dementia and Alzheimer’s disease. [1] Centrophenoxine is a derivative of dimethylethanolamine (DMAE) and is an ester of DMAE and 4-chlorophenoxyacetic acid (pCPA).

DMAE is a choline-like molecule with the ability to reduce buildup of the ‘age pigment’ and increase acetylcholine levels. DMAE occurs naturally in many food sources. The binding of DMAE to pCPA enhances its absorption and creates a much more effective cognition-enhancing compound.

In elderly patients, studies on Centrophenoxine (meclofenoxate) have shown clinically significant improvements in memory and cognition, along with a mental stimulation effect.[3] In many European countries and some countries in Asia, Centrophenoxine is sold as a prescription drug. In other parts of the world, it is available either as a dietary supplement or a research chemical. Centrophenoxine was reported developed in 1959 at the French National Scientific Research Center. [4]

References

[1] Nehru B. (2006). “Evidence for centrophenoxine as a protective drug in aluminium induced behavioral and biochemical alteration in rat brain”. Mol Cell Biochem. 290(1-2):33-42. doi: 10.1007/s11010-006-9125-7. PMID: 16969689.

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