|Molecular Weight||325.3 g/mol|
|Synonyms||Fladrafinil, CRL-40,941, Acetamide, 2-[[bis(4-fluorophenyl)methyl]sulfinyl]-N-hydroxy-
|Application||CRL-40,941 (Fladrafinil) is an eugeroic related to and of higher potency than adrafinil, with anticonflict properties.|
|Appearance||White to pale cream powder|
|Solubility||Poorly soluble in water; Soluble to 5 mg / mL in ethanol; Soluble to 10 mg / mL in isopropanol|
|Storage||Store at room temperature or cooler, in a sealed airtight container, protected from heat, light and humidity.|
|Stability||Stable for at least two years when stored as above.|
CRL-40,941 (Fladrafinil) is a psychotonic and eurgeroic (wakefulness-promoting substance) that is related to Adrafinil and CRL-40,940, with similar but more potent effects demonstrated in animal models. Fladrafinil is the bis(p-fluoro) derivative of Adrafinil, and is, therefore, often referred to as “Fladrafinil”. Unfortunately, very little literature currently exists for this compound.
Unlike its parent compound, CRL-40, 941 also appears to demonstrate some interesting anti-aggressive (calming) properties in animal studies – according to the original 1983 patent filed by the Parisian Laboratoire L. Lafon. In the late 1970s, this French laboratory was where compounds such as Modafinil, CRL-40-940, and CRL-40,941 were initially developed as a family of eugeroics, with research led by Dr. Michel Jouvet.
The research team at Laboratoire Lafon observed that CRL-40,941 had similar psychotonic and eurgeroic properties as Adrafinil – albeit with improved bioavailability through oral administration. The unique characteristic of CRL-40,941 is its anti-aggressive properties in animal models, which sets it apart from both Modafinil and Adrafinil.
 Geraldine D. (2016). “Outsmarted by nootropics? An investigation into the thermal degradation of modafinil, modafinic acid, adrafinil, CRL-40,940 and CRL-40,941 in the GC injector: formation of 1,1,2,2-tetraphenylethane and its tetra fluoro analog”. Drug Test Anal. 2017 Mar;9(3): 518-528. doi: 10.1002/dta.2142. PMID: 27928893.