Buy Fladrafinil (CRL-40,941) Powder 99.63% Pure – Chemical Exchange

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Buy Fladrafinil (CRL-40,941) Powder 99.63% Pure

Fladrafinil (CRL-40,941)

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CRL-40,941 (Fladrafinil) is a psychotonic and eurgeroic (wakefulness-promoting substance) that is related to Adrafinil and CRL-40,940, with similar but more potent effects demonstrated in animal models.

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Chemical Information

CAS Number 90212-80-9
Purity 99.6%
Molecular Weight 325.3 g/mol
Molecular Formula C15H13F2NO3S
Synonyms Fladrafinil, CRL-40,941, Acetamide, 2-[[bis(4-fluorophenyl)methyl]sulfinyl]-N-hydroxy-
2-[bis(4-fluorophenyl)methylsulfinyl]-N-hydroxyacetamide
PubChem CID 13316557
Smiles C1=CC(=CC=C1C(C2=CC=C(C=C2)F)S(=O)CC(=O)NO)F

Technical Information

Application CRL-40,941 (Fladrafinil) is an eugeroic related to and of higher potency than adrafinil, with anticonflict properties.
Appearance White to pale cream powder
Physical State Solid
Solubility Poorly soluble in water; Soluble to 5 mg / mL in ethanol; Soluble to 10 mg / mL in isopropanol
Storage Store at room temperature or cooler, in a sealed airtight container, protected from heat, light and humidity.
Stability Stable for at least two years when stored as above.

Biochemical Activity

CRL-40,941 (Fladrafinil) is a psychotonic and eurgeroic (wakefulness-promoting substance) that is related to Adrafinil and CRL-40,940, with similar but more potent effects demonstrated in animal models. Fladrafinil is the bis(p-fluoro) derivative of Adrafinil, and is, therefore, often referred to as “Fladrafinil”. Unfortunately, very little literature currently exists for this compound.

Unlike its parent compound, CRL-40, 941 also appears to demonstrate some interesting anti-aggressive (calming) properties in animal studies – according to the original 1983 patent filed by the Parisian Laboratoire L. Lafon. In the late 1970s, this French laboratory was where compounds such as Modafinil, CRL-40-940, and CRL-40,941 were initially developed as a family of eugeroics, with research led by Dr. Michel Jouvet.

The research team at Laboratoire Lafon observed that CRL-40,941 had similar psychotonic and eurgeroic properties as Adrafinil – albeit with improved bioavailability through oral administration. The unique characteristic of CRL-40,941 is its anti-aggressive properties in animal models, which sets it apart from both Modafinil and Adrafinil.

References

[1] Geraldine D. (2016). “Outsmarted by nootropics? An investigation into the thermal degradation of modafinil, modafinic acid, adrafinil, CRL-40,940 and CRL-40,941 in the GC injector: formation of 1,1,2,2-tetraphenylethane and its tetra fluoro analog”. Drug Test Anal. 2017 Mar;9(3): 518-528. doi: 10.1002/dta.2142. PMID: 27928893.

Lab Analysis

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