Chemical Information
| CAS Number | 90212-80-9 |
| Purity | 98.5% |
| Molecular Weight | 325.3 g/mol |
| Molecular Formula | C15H13F2NO3S |
| Synonyms | Fladrafinil, CRL-40,941, Acetamide, 2-[[bis(4-fluorophenyl)methyl]sulfinyl]-N-hydroxy- 2-[bis(4-fluorophenyl)methylsulfinyl]-N-hydroxyacetamide |
| PubChem CID | 13316557 |
| Smiles | C1=CC(=CC=C1C(C2=CC=C(C=C2)F)S(=O)CC(=O)NO)F |
Technical Information
| Application | CRL-40,941 (Fladrafinil) is an eugeroic related to and of higher potency than adrafinil, with anticonflict properties. |
| Appearance | White to pale cream powder |
| Physical State | Solid |
| Solubility | Poorly soluble in water; Soluble to 5 mg / mL in ethanol; Soluble to 10 mg / mL in isopropanol |
| Storage | Store at room temperature or cooler, in a sealed airtight container, protected from heat, light and humidity. |
| Stability | Stable for at least two years when stored as above. |
Biochemical Activity
CRL-40,941 (Fladrafinil) is a psychotonic and eurgeroic (wakefulness-promoting substance) that is related to Adrafinil and CRL-40,940, with similar but more potent effects demonstrated in animal models. Fladrafinil is the bis(p-fluoro) derivative of Adrafinil, and is, therefore, often referred to as “Fladrafinil”. Unfortunately, very little literature currently exists for this compound.
Unlike its parent compound, CRL-40, 941 also appears to demonstrate some interesting anti-aggressive (calming) properties in animal studies – according to the original 1983 patent filed by the Parisian Laboratoire L. Lafon. In the late 1970s, this French laboratory was where compounds such as Modafinil, CRL-40-940, and CRL-40,941 were initially developed as a family of eugeroics, with research led by Dr. Michel Jouvet.
The research team at Laboratoire Lafon observed that CRL-40,941 had similar psychotonic and eurgeroic properties as Adrafinil – albeit with improved bioavailability through oral administration. The unique characteristic of CRL-40,941 is its anti-aggressive properties in animal models, which sets it apart from both Modafinil and Adrafinil.
References
[1] Geraldine D. (2016). “Outsmarted by nootropics? An investigation into the thermal degradation of modafinil, modafinic acid, adrafinil, CRL-40,940 and CRL-40,941 in the GC injector: formation of 1,1,2,2-tetraphenylethane and its tetra fluoro analog”. Drug Test Anal. 2017 Mar;9(3): 518-528. doi: 10.1002/dta.2142. PMID: 27928893.
