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F-Phenibut HCL

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F-Phenibut HCl (4-Fluorophenibut hydrochloride) is a several-fold more potent derivative of the nootropic and anxiolytic GABA derivative, Phenibut.

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Chemical Information

CAS Number 52237-19-1
Purity 99.6%
Molecular Weight 197.21 g/mol
Molecular Formula C10H12FNO2
Synonyms 4-Fluorophenibut, β-(4-fluorophenyl)-γ-aminobutyric acid, CGP-11130, Fluorophenibut, F-Phenibut, Fluoribut, Fenibut
PubChem CID 103611
Smiles C1=CC(=CC=C1C(CC(=O)O)CN)F

Technical Information

Application F-Phenibut HCl (4-Fluorophenibut hydrochloride) is a several-fold more potent derivative of the nootropic and anxiolytic gamma amino butyric acid derivative, Phenibut; useful as a GABAB and α2δ subunit-containing voltage-gated calcium channel ligand
Appearance White or off-white crystalline powder
Physical State Solid
Solubility Freely soluble in Ethanol, Water.
Storage Store at room temperature or cooler, in a sealed airtight container, protected from heat, light and humidity.
Stability Stable for at least two years when stored as above.

Biochemical Activity

F-Phenibut HCl (4-Fluorophenibut hydrochloride) is a several-fold more potent derivative of Phenibut. Phenibut is an atypical anxiolytic and nootropic compound structurally similar to the well known inhibitory neurotransmitter GABA, as well as to baclofen (β-(4-chlorophenyl)-GABA) and pregabalin (β-isobutyl-GABA). Phenibut was originally thought to act solely as a selective GABAB receptor agonist, similar to its much more potent relative baclofen, but has more recently been found to additionally act with somewhat higher affinity as an inhibitor of α2δ subunit-containing voltage-gated calcium channels, a mechanism of action shared with gabapentin and pregabalin.


[1] Lapin I. (2001). “Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug”. CNS Drug Reviews 7 (4): 471–481. doi: 10.1111/j.1527-3458.2001.tb00211.x. PMID: 11830761.

Additional information

Weight .1 lbs
Dimensions 1 × 1 × 1 in

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