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Noopept

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Noopept is a medication promoted and prescribed in Russia and neighbouring countries as a nootropic.

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Chemical Information

CAS Number 157115-85-0
Purity 99.6%
Molecular Weight 318.4 g/mol
Molecular Formula C17H22N2O4
Synonyms ethyl phenylacetyl-Pro-Gly, GVS 111, GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester, noopept
PubChem CID 180496
Smiles CCOC(=O)CNC(=O)C1CCCN1C(=O)CC2=CC=CC=C2

Technical Information

Application A nootropic agent derived from the racetam family. Stimulates the expression of NGF and BDNF in rat hippocampus.
Appearance White Powder
Physical State Solid
Solubility Soluble to 25 mM in Ethanol, Sparingly soluble in Water.
Storage Store at room temperature or cooler, in a sealed airtight container, protected from heat, light and humidity.
Stability Stable for at least two years when stored as above.

Biochemical Activity

Noopept (GVS-111) is a compound with neuroprotective and cognition enhancing properties that is derived from the racetam family. It is used in neuroscience studies and in research related to protection against cognitive impairment. Animal studies have shown Noopept to be neuroprotective and enhance memory in various tests.

Noopept has been shown to have anti-inflammatory action in rats and mice, and to normalize the response of benzodiazepine binding to stress. Chronic administration of Noopept decreases the activity of stress-induced kinases and increases the expression of BDNF in the hypothalamus and hippocampus in rats.

Noopept shows competitive binding to AMPA receptor sites in the rat brain with IC50 of 80 microM. Noopept appears to have concentration-dependent effects on the DNA-binding activity of transcriptional factor HIF-1. Furthermore, it appears to have neuroprotective effects in PC12 cells by protecting against oxidative damage and tau phosphorylation.

In animal studies, the phagocytic activity of macrophages was increased along with stimulated immune response to various antigens, and increased activity of white blood cells in the spleen.

References

[1] Gürbüz P. (2019). “Effects of noopept on cognitive functions and pubertal process in rats with diabetes”. Life Sci. 233:116698. doi: 10.1016/j.lfs.2019.116698. PMID: 31356906.

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