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Phenibut

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Phenibut, sold under the brand names Anvifen, Fenibut, and Noofen among others, is a central nervous system depressant with anxiolytic and stimulant effects which is used in the treatment of anxiety, insomnia, and for a variety of other indications.

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Chemical Information

CAS Number 1078-21-3
Purity 99.6%
Molecular Weight 179.22 g/mol
Molecular Formula C10H13NO2
Synonyms 4-Amino-3-phenylbutanoic acid, Phenibut, 1078-21-3, Fenibut, Phenylgamma, Fenigama, Phenigam, Phenylgam
PubChem CID 14113
Smiles C1=CC=C(C=C1)C(CC(=O)O)CN

Technical Information

Application Phenibut is a neuropsychotropic drug that was discovered and introduced into clinical practice in Russia in the 1960s.
Appearance Crystalline Powder
Physical State Solid
Solubility Freely soluble in ethanol and water.
Storage Store at room temperature or cooler, in a sealed airtight container, protected from heat, light and humidity.
Stability Stable for at least two years when stored as above.

Biochemical Activity

Phenibut (beta-phenyl-gamma-aminobutyric acid HCl) is a neuropsychotropic drug that was discovered and introduced into clinical practice in Russia in the 1960s. It has anxiolytic and nootropic (cognition enhancing) effects. It acts as a GABA-mimetic, primarily at GABA(B) and, to some extent, at GABA(A) receptors. It also stimulates dopamine receptors and antagonizes beta-phenethylamine (PEA), a putative endogenous anxiogenic. The psychopharmacological activity of phenibut is similar to that of baclofen, a p-Cl-derivative of phenibut. This article reviews the structure-activity relationship of phenibut and its derivatives. Emphasis is placed on the importance of the position of the phenyl ring, the role of the carboxyl group, and the activity of optical isomers. Comparison of phenibut with piracetam and diazepam reveals similarities and differences in their pharmacological and clinical effects. Phenibut is widely used in Russia to relieve tension, anxiety, and fear, to improve sleep in psychosomatic or neurotic patients; as well as a pre- or post-operative medication. It is also used in the therapy of disorders characterized by asthenia and depression, as well as in post-traumatic stress, stuttering and vestibular disorders.

References

[1] Lapin I. (2001). “Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug”. CNS Drug Reviews 7 (4): 471–481. doi: 10.1111/j.1527-3458.2001.tb00211.x. PMID: 11830761.

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