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1,3-Dimethylamylamine

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1,3-Dimethylamylamine (DMAA) is a stimulant existing in various pre-workout supplements and often labelled as part of geranium plants. The safety and origin of DMAA in these supplements is the subject of intense debate.

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Chemical Information

CAS Number 105-41-9
Purity 99.6%
Molecular Weight 115.22 g/mol
Molecular Formula C7H17N
Synonyms 1,3-Dimethylamylamine, 1,3-Dimethylpentylamine, Geranamine, Methylhexanamine, 1,3-DMAA, 2-Amino-4-Methylhexane
PubChem CID 7753
Smiles CCC(C)CC(C)N

Technical Information

Application Indirect sympathomimetic drug, which mimics the effects of endogenous agonists of the sympathetic nervous system.
Appearance White Powder
Physical State Solid
Solubility Slightly soluble in water; very soluble in ethanol, ether, chloroform and dilute acid.
Storage Store at room temperature or cooler, in a sealed airtight container, protected from heat, light and humidity.
Stability Stable for at least two years when stored as above.

Biochemical Activity

1,3-dimethylamylamine (DMAA) has been a component of dietary supplements and is also used within “party pills,” often in conjunction with alcohol and other drugs. Ingestion of higher than recommended doses results in untoward effects including cerebral hemorrhage. To our knowledge, no studies have been conducted to determine both the pharmacokinetic profile and physiologic responses of DMAA.

References

[1] Shilling B. (2013). “Physiological and pharmacokinetic effects of oral 1,3-dimethylamylamine administration in men”. Clinical Trial doi: 10.1186/2050-6511-14-52. PMID: 24090077.

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